8SRC

Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium and ADP-ribose

Summary for 8SRC

• Entry DOI: 10.2210/pdb8src/pdb
• EMDB information: 40726 40865 40893
• Descriptor: TRPM2 chanzyme, ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: trpm2 chanzyme, channel-enzyme, transport protein
• Biological source: Salpingoeca rosetta
• Total number of polymer chains: 4
• Total formula weight: 682805.64

Authors

Huang, Y.,Kumar, S.,Lu, W.,Du, J. (deposition date: 2023-05-05, release date: 2024-05-08, Last modification date: 2024-06-05)

• Primary citation: Huang, Y.,Kumar, S.,Lee, J.,Lu, W.,Du, J.; Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.; Nat.Struct.Mol.Biol., 2024; PubMed: 38773335; DOI: 10.1038/s41594-024-01316-4

Experimental method

ELECTRON MICROSCOPY (2.92 Å)