8SP2

Crystal structure of metformin hydrolase (MfmAB) from Pseudomonas mendocina sp. MET-2 apo form

Summary for 8SP2

Entry DOI	10.2210/pdb8sp2/pdb
Related	8SNF 8SNK
Descriptor	metformin hydrolase subunit B, metformin hydrolase subunit A, NICKEL (II) ION, ... (4 entities in total)
Functional Keywords	ureohydrolase, metformin, metalloenzyme, guanylurea, hydrolase
Biological source	Pseudomonas mendocina More
Total number of polymer chains	12
Total formula weight	467559.73
Authors	Tassoulas, L.J.,Rankin, J.A.,Elias, M.H.,Wackett, L.P. (deposition date: 2023-05-01, release date: 2024-03-06)
Primary citation	Tassoulas, L.J.,Rankin, J.A.,Elias, M.H.,Wackett, L.P. Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes. Proc.Natl.Acad.Sci.USA, 121:e2312652121-e2312652121, 2024 Cited by PubMed: 38408229 DOI: 10.1073/pnas.2312652121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation