8SOS

Human CD1d presenting sphingomyelin C24:1 in complex with VHH nanobody 1D17

Summary for 8SOS

• Entry DOI: 10.2210/pdb8sos/pdb
• Descriptor: Antigen-presenting glycoprotein CD1d, Beta-2-microglobulin, Nanobody VHH ID17, ... (6 entities in total)
• Functional Keywords: cd1d, sphingomyelin, nkt, nanobody, vhh, 1d17, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 132974.47

Authors

Shahine, A.,Rossjohn, J. (deposition date: 2023-04-29, release date: 2023-12-13, Last modification date: 2024-10-30)

Primary citation

Lameris, R.,Shahine, A.,Veth, M.,Westerman, B.,Godfrey, D.I.,Lutje Hulsik, D.,Brouwer, P.,Rossjohn, J.,de Gruijl, T.D.,van der Vliet, H.J.
Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions.
J Immunother Cancer, 11:-, 2023

PubMed Abstract: CD1d is a monomorphic major histocompatibility complex class I-like molecule that presents lipid antigens to distinct T-cell subsets and can be expressed by various malignancies. Antibody-mediated targeting of CD1d on multiple myeloma cells was reported to induce apoptosis and could therefore constitute a novel therapeutic approach.

PubMed: 38040419
DOI: 10.1136/jitc-2023-007631

Experimental method

X-RAY DIFFRACTION (2.33 Å)