8SMS
Crosslinked Crystal Structure of Type II Fatty Acid Synthase, FabB, and cerulenin crosslinker-crypto Acyl Carrier Protein, AcpP
Summary for 8SMS
Entry DOI | 10.2210/pdb8sms/pdb |
Descriptor | 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(2R)-2-hydroxy-4-oxododecanamido]ethyl}-beta-alaninamide, ... (4 entities in total) |
Functional Keywords | ketosynthase, fabb, acpp, acyl carrier protein, cerulenin, crosslinker, crosslink, fatty acid biosynthesis, natural product, biosynthetic protein |
Biological source | Escherichia coli K-12 More |
Total number of polymer chains | 4 |
Total formula weight | 103327.95 |
Authors | Jiang, Z.,Chen, A.,Chen, J.,Sekhon, A.,Louie, G.V.,Noel, J.P.,La Clair, J.J.,Burkart, M.D. (deposition date: 2023-04-26, release date: 2023-09-27, Last modification date: 2023-10-25) |
Primary citation | Jiang, Z.,Chen, A.,Chen, J.,Sekhon, A.,Louie, G.V.,Noel, J.P.,La Clair, J.J.,Burkart, M.D. Masked cerulenin enables a dual-site selective protein crosslink. Chem Sci, 14:10925-10933, 2023 Cited by PubMed: 37829009DOI: 10.1039/d3sc02864j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)