8SMS

Crosslinked Crystal Structure of Type II Fatty Acid Synthase, FabB, and cerulenin crosslinker-crypto Acyl Carrier Protein, AcpP

8SMS の概要

• エントリーDOI: 10.2210/pdb8sms/pdb
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(2R)-2-hydroxy-4-oxododecanamido]ethyl}-beta-alaninamide, ... (4 entities in total)
• 機能のキーワード: ketosynthase, fabb, acpp, acyl carrier protein, cerulenin, crosslinker, crosslink, fatty acid biosynthesis, natural product, biosynthetic protein
• 由来する生物種: Escherichia coli K-12; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 103327.95

構造登録者

Jiang, Z.,Chen, A.,Chen, J.,Sekhon, A.,Louie, G.V.,Noel, J.P.,La Clair, J.J.,Burkart, M.D. (登録日: 2023-04-26, 公開日: 2023-09-27, 最終更新日: 2023-10-25)

• 主引用文献: Jiang, Z.,Chen, A.,Chen, J.,Sekhon, A.,Louie, G.V.,Noel, J.P.,La Clair, J.J.,Burkart, M.D.; Masked cerulenin enables a dual-site selective protein crosslink.; Chem Sci, 14:10925-10933, 2023; PubMed: 37829009; DOI: 10.1039/d3sc02864j

実験手法

X-RAY DIFFRACTION (1.93 Å)