8SLZ

Crystal structure of phosphorylated (T357/S358) human MLKL pseudokinase domain

Summary for 8SLZ

Entry DOI	10.2210/pdb8slz/pdb
Descriptor	Mixed lineage kinase domain-like protein (2 entities in total)
Functional Keywords	pseudokinase, phosphorylation, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32896.71
Authors	Meng, Y.,Davies, K.A.,Czabotar, P.E.,Murphy, J.M. (deposition date: 2023-04-25, release date: 2023-11-08)
Primary citation	Meng, Y.,Garnish, S.E.,Davies, K.A.,Black, K.A.,Leis, A.P.,Horne, C.R.,Hildebrand, J.M.,Hoblos, H.,Fitzgibbon, C.,Young, S.N.,Dite, T.,Dagley, L.F.,Venkat, A.,Kannan, N.,Koide, A.,Koide, S.,Glukhova, A.,Czabotar, P.E.,Murphy, J.M. Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization. Nat Commun, 14:6804-6804, 2023 Cited by PubMed: 37884510 DOI: 10.1038/s41467-023-42255-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation