8SL9

Crystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73

Summary for 8SL9

• Entry DOI: 10.2210/pdb8sl9/pdb
• Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: francisella tularensis, hppk-dhps, bisubstrate inhibitor, hp-73, transferase
• Biological source: Francisella tularensis subsp. tularensis
• Total number of polymer chains: 1
• Total formula weight: 50572.48

Authors

Shaw, G.X.,Shi, G.,Cherry, S.,Needle, D.,Tropea, J.E.,Waugh, D.S.,Ji, X. (deposition date: 2023-04-21, release date: 2024-05-01)

• Primary citation: Shaw, G.X.,Shi, G.,Cherry, S.,Needle, D.,Tropea, J.E.,Waugh, D.S.,Ji, X.; Crystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73; To be published,

Experimental method

X-RAY DIFFRACTION (1.4 Å)