8SL7
Butyricicoccus sp. BIOML-A1 tryptophanase complex with (3S) ALG-05
Summary for 8SL7
Entry DOI | 10.2210/pdb8sl7/pdb |
Descriptor | Tryptophanase, (E)-3-[(3S)-3-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine (3 entities in total) |
Functional Keywords | tryptophan-indole lyase, tryptophananse, plp-dependent enzyme, inhibitor-bound complex, lyase |
Biological source | Butyricicoccus sp. BIOML-A1 |
Total number of polymer chains | 4 |
Total formula weight | 260638.62 |
Authors | Graboski, A.L.,Redinbo, M.R. (deposition date: 2023-04-21, release date: 2023-08-23, Last modification date: 2023-11-29) |
Primary citation | Graboski, A.L.,Kowalewski, M.E.,Simpson, J.B.,Cao, X.,Ha, M.,Zhang, J.,Walton, W.G.,Flaherty, D.P.,Redinbo, M.R. Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate. Cell Chem Biol, 30:1402-1413.e7, 2023 Cited by PubMed: 37633277DOI: 10.1016/j.chembiol.2023.07.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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