8SL7

Butyricicoccus sp. BIOML-A1 tryptophanase complex with (3S) ALG-05

8SL7 の概要

• エントリーDOI: 10.2210/pdb8sl7/pdb
• 分子名称: Tryptophanase, (E)-3-[(3S)-3-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine (3 entities in total)
• 機能のキーワード: tryptophan-indole lyase, tryptophananse, plp-dependent enzyme, inhibitor-bound complex, lyase
• 由来する生物種: Butyricicoccus sp. BIOML-A1
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 260638.62

構造登録者

Graboski, A.L.,Redinbo, M.R. (登録日: 2023-04-21, 公開日: 2023-08-23, 最終更新日: 2023-11-29)

• 主引用文献: Graboski, A.L.,Kowalewski, M.E.,Simpson, J.B.,Cao, X.,Ha, M.,Zhang, J.,Walton, W.G.,Flaherty, D.P.,Redinbo, M.R.; Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.; Cell Chem Biol, 30:1402-1413.e7, 2023; PubMed: 37633277; DOI: 10.1016/j.chembiol.2023.07.015

実験手法

X-RAY DIFFRACTION (2.07 Å)