8SKL

PTP1B in complex with 182

Summary for 8SKL

Entry DOI	10.2210/pdb8skl/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, CHLORIDE ION, SODIUM ION, ... (6 entities in total)
Functional Keywords	phosphatase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38193.29
Authors	Babon, J.J.,Chen, H.,Tiganis, T. (deposition date: 2023-04-20, release date: 2023-08-02, Last modification date: 2023-08-16)
Primary citation	Liang, S.,Tran, E.,Du, X.,Dong, J.,Sudholz, H.,Chen, H.,Qu, Z.,Huntington, N.D.,Babon, J.J.,Kershaw, N.J.,Zhang, Z.Y.,Baell, J.B.,Wiede, F.,Tiganis, T. A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity. Nat Commun, 14:4524-4524, 2023 Cited by PubMed: 37500611 DOI: 10.1038/s41467-023-40170-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation