8SK5

Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain

8SK5 の概要

• エントリーDOI: 10.2210/pdb8sk5/pdb
• 分子名称: Spike protein S1, anti-SARS-CoV-2 receptor binding domain VHH, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: vhh, complex, antiviral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44890.66

構造登録者

Noland, C.L.,Pande, K.,Zhang, L.,Zhou, H.,Galli, J.,Eddins, M.,Gomez-Llorente, Y. (登録日: 2023-04-18, 公開日: 2023-08-16, 最終更新日: 2023-09-06)

• 主引用文献: Hollingsworth, S.A.,Noland, C.L.,Vroom, K.,Saha, A.,Sam, M.,Gao, Q.,Zhou, H.,Grandy, D.U.,Singh, S.,Wen, Z.,Warren, C.,Ma, X.S.,Malashock, D.,Galli, J.,Go, G.,Eddins, M.,Mayhood, T.,Sathiyamoorthy, K.,Fridman, A.,Raoufi, F.,Gomez-Llorente, Y.,Patridge, A.,Tang, Y.,Chen, S.J.,Bailly, M.,Ji, C.,Kingsley, L.J.,Cheng, A.C.,Geierstanger, B.H.,Gorman, D.M.,Zhang, L.,Pande, K.; Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants.; Sci Rep, 13:13668-13668, 2023; PubMed: 37608223; DOI: 10.1038/s41598-023-40919-7

実験手法