8SE5

NKG2D complexed with inhibitor 14

Summary for 8SE5

Entry DOI	10.2210/pdb8se5/pdb
Descriptor	NKG2-D type II integral membrane protein, TRIETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywords	nkg2d, immune system, immunosuppressant-inhibitor complex, immune system-inhibitor complex, immune system/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	31030.98
Authors	Thompson, A.A.,Grant, J.C.,Karpowich, N.K.,Sharma, S. (deposition date: 2023-04-08, release date: 2023-10-11, Last modification date: 2023-11-01)
Primary citation	Wang, J.,Nakafuku, K.M.,Ziff, J.,Gelin, C.F.,Gholami, H.,Thompson, A.A.,Karpowich, N.K.,Limon, L.,Coate, H.R.,Damm-Ganamet, K.L.,Shih, A.Y.,Grant, J.C.,Cote, M.,Mak, P.A.,Pascual, H.A.,Rives, M.L.,Edwards, J.P.,Venable, J.D.,Venkatesan, H.,Shi, Z.,Allen, S.J.,Sharma, S.,Kung, P.P.,Shireman, B.T. Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D). Bioorg.Med.Chem.Lett., 96:129492-129492, 2023 Cited by PubMed: 37778428 DOI: 10.1016/j.bmcl.2023.129492 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation