8SE5

NKG2D complexed with inhibitor 14

8SE5 の概要

• エントリーDOI: 10.2210/pdb8se5/pdb
• 分子名称: NKG2-D type II integral membrane protein, TRIETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• 機能のキーワード: nkg2d, immune system, immunosuppressant-inhibitor complex, immune system-inhibitor complex, immune system/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31030.98

構造登録者

Thompson, A.A.,Grant, J.C.,Karpowich, N.K.,Sharma, S. (登録日: 2023-04-08, 公開日: 2023-10-11, 最終更新日: 2023-11-01)

• 主引用文献: Wang, J.,Nakafuku, K.M.,Ziff, J.,Gelin, C.F.,Gholami, H.,Thompson, A.A.,Karpowich, N.K.,Limon, L.,Coate, H.R.,Damm-Ganamet, K.L.,Shih, A.Y.,Grant, J.C.,Cote, M.,Mak, P.A.,Pascual, H.A.,Rives, M.L.,Edwards, J.P.,Venable, J.D.,Venkatesan, H.,Shi, Z.,Allen, S.J.,Sharma, S.,Kung, P.P.,Shireman, B.T.; Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).; Bioorg.Med.Chem.Lett., 96:129492-129492, 2023; PubMed: 37778428; DOI: 10.1016/j.bmcl.2023.129492

実験手法

X-RAY DIFFRACTION (1.43 Å)