8SDX

ATAD2B bromodomain in complex with histone H4 acetylated at lysine 5 with Serine 1 mutation to Cysteine

8SDX の概要

• エントリーDOI: 10.2210/pdb8sdx/pdb
• 分子名称: ATPase family AAA domain-containing protein 2B, histone H4S1CK5ac, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: bromodomains, epigenetics, chromatin reader domain, protein binding, nuclear protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 34443.39

構造登録者

Phillips, M.,Montgomery, C.,Nix, J.C.,Glass, K.C. (登録日: 2023-04-07, 公開日: 2024-06-05)

• 主引用文献: Phillips, M.,Malone, K.L.,Boyle, B.W.,Montgomery, C.,Kressy, I.A.,Joseph, F.M.,Bright, K.M.,Boyson, S.P.,Chang, S.,Nix, J.C.,Young, N.L.,Jeffers, V.,Frietze, S.,Glass, K.C.; Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains.; J.Med.Chem., 67:8186-8200, 2024; PubMed: 38733345; DOI: 10.1021/acs.jmedchem.4c00210

実験手法

X-RAY DIFFRACTION (2.69 Å)