8S6Y

Co-crystal structure of TEAD1 with OPN-9652

This is a non-PDB format compatible entry.

Summary for 8S6Y

• Entry DOI: 10.2210/pdb8s6y/pdb
• Descriptor: Transcriptional enhancer factor TEF-1, 1-[7-[3-fluoranyl-4-(trifluoromethyl)phenoxy]-3,4-dihydro-1~{H}-isoquinolin-2-yl]propan-1-one, 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: tead inhibitor, tead1, auto-palmitoylation pocket, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 104628.51

Authors

Aplin, A.E. (deposition date: 2024-02-28, release date: 2025-07-30)

• Primary citation: Aplin, A.E.; Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.031 Å)