8S65

1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii compounds: crystal structure, biochemical characterization and biological evaluation of inhibitors

8S65 の概要

• エントリーDOI: 10.2210/pdb8s65/pdb
• 分子名称: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, ... (6 entities in total)
• 機能のキーワード: 1-deoxy-d-xylulose-5-phosphate reductoisomerase, structural protein
• 由来する生物種: Toxoplasma gondii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 105796.46

構造登録者

Mazzone, F.,Hoeppner, A.,Reiners, J.,Applegate, V.,Abdullaziz, M.,Gottstein, J.,Wesemann, M.,Kurz, T.,Smits, S.H.,Pfeffer, K. (登録日: 2024-02-26, 公開日: 2024-08-21)

• 主引用文献: Mazzone, F.,Hoeppner, A.,Reiners, J.,Gertzen, C.G.W.,Applegate, V.,Abdullaziz, M.A.,Gottstein, J.,Degrandi, D.,Wesemann, M.,Kurz, T.,Smits, S.H.,Pfeffer, K.; 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterisation and biological evaluation of inhibitors.; Biochem.J., 2024; PubMed: 39105673; DOI: 10.1042/BCJ20240110

実験手法

SOLUTION SCATTERING
X-RAY DIFFRACTION (2.56 Å)