8S3R
HUMAN PI3KDELTA IN COMPLEX WITH PYRIDAZINONE INHIBITOR 7
This is a non-PDB format compatible entry.
Summary for 8S3R
Entry DOI | 10.2210/pdb8s3r/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 5-[(1~{S})-1-[4-azanyl-3-(5-oxidanylpyridin-3-yl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-4-cyclopentyl-2-(phenylmethyl)pyridazin-3-one, ... (4 entities in total) |
Functional Keywords | pi3kdelta kinase, pi3kdelta kinase inhibitor, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 137988.76 |
Authors | Pala, D.,Bruno, P.,Capelli, A.M.,Biagetti, M. (deposition date: 2024-02-20, release date: 2024-07-03) |
Primary citation | Bruno, P.,Micoli, A.,Corsi, M.,Pala, D.,Guariento, S.,Fiorelli, C.,Ronchi, P.,Fioni, A.,Gallo, P.M.,Marenghi, G.,Bertolini, S.,Capacchi, S.,Mileo, V.,Biagetti, M.,Capelli, A.M. Discovery and Optimization of Pyridazinones as PI3K delta Selective Inhibitors for Administration by Inhalation. J.Med.Chem., 2024 Cited by PubMed: 38907711DOI: 10.1021/acs.jmedchem.4c00610 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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