8S17

c-KIT kinase domain in complex with ponatinib

Summary for 8S17

• Entry DOI: 10.2210/pdb8s17/pdb
• Descriptor: Mast/stem cell growth factor receptor Kit, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: stem cell factor receptor, gist, inhibitor, gatekeeper mutation, resistance, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 75595.79

Authors

Teuber, A.,Mueller, M.P.,Rauh, D. (deposition date: 2024-02-15, release date: 2025-09-03)

• Primary citation: Teuber, A.,Niggenaber, J.,Kleinboelting, S.B.,Landel, I.,Warmuth, J.,Busick, D.,Mueller, M.P.,Bauer, S.,Rauh, D.; c-KIT kinase domain in complex with ponatinib; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)