8S17

c-KIT kinase domain in complex with ponatinib

8S17 の概要

• エントリーDOI: 10.2210/pdb8s17/pdb
• 分子名称: Mast/stem cell growth factor receptor Kit, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: stem cell factor receptor, gist, inhibitor, gatekeeper mutation, resistance, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75595.79

構造登録者

Teuber, A.,Mueller, M.P.,Rauh, D. (登録日: 2024-02-15, 公開日: 2025-09-03)

• 主引用文献: Teuber, A.,Niggenaber, J.,Kleinboelting, S.B.,Landel, I.,Warmuth, J.,Busick, D.,Mueller, M.P.,Bauer, S.,Rauh, D.; c-KIT kinase domain in complex with ponatinib; To Be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)