8RY2

Crystal Structure of ANV419, a novel IL-2/anti-IL-2 antibody fusion protein

8RY2 の概要

• エントリーDOI: 10.2210/pdb8ry2/pdb
• 分子名称: ANV419 heavy-chain, ANV419 light-chain (3 entities in total)
• 機能のキーワード: immuno-oncology, cytokine
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 126496.00

構造登録者

Rondeau, J.M.,Wirth, E. (登録日: 2024-02-08, 公開日: 2024-07-31)

• 主引用文献: Murer, P.,Brannetti, B.,Rondeau, J.M.,Petersen, L.,Egli, N.,Popp, S.,Regnier, C.,Richter, K.,Katopodis, A.,Huber, C.; Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy.; Mabs, 16:2381891-2381891, 2024; PubMed: 39041287; DOI: 10.1080/19420862.2024.2381891

実験手法

X-RAY DIFFRACTION (2.05 Å)