8RPL

AMP-forming acetyl-CoA synthetase from Chloroflexota bacterium with bound acetyl AMP

Summary for 8RPL

• Entry DOI: 10.2210/pdb8rpl/pdb
• Descriptor: Acetate--CoA ligase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] ethanoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
• Functional Keywords: acetate, acetyl-amp, coa, phospho histidine, acsa, ligase
• Biological source: Chloroflexota bacterium
• Total number of polymer chains: 4
• Total formula weight: 299072.22

Authors

Striska, K.,Palm, G.J.,Lammers, M. (deposition date: 2024-01-16, release date: 2024-06-19)

• Primary citation: Qin, C.,Lammers, M.; The AMP-forming acetyl-CoA-synthetase is regulated by lysine acetylation and has an intrinsic phosphotransacetylase activity to adjust its activity to the cellular acetyl-phosphate level; Nature Comm, 2024

Experimental method

X-RAY DIFFRACTION (2.37 Å)