8RPL

AMP-forming acetyl-CoA synthetase from Chloroflexota bacterium with bound acetyl AMP

Summary for 8RPL

Entry DOI	10.2210/pdb8rpl/pdb
Descriptor	Acetate--CoA ligase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] ethanoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
Functional Keywords	acetate, acetyl-amp, coa, phospho histidine, acsa, ligase
Biological source	Chloroflexota bacterium
Total number of polymer chains	4
Total formula weight	299072.22
Authors	Striska, K.,Palm, G.J.,Lammers, M. (deposition date: 2024-01-16, release date: 2024-06-19, Last modification date: 2024-07-31)
Primary citation	Qin, C.,Graf, L.G.,Striska, K.,Janetzky, M.,Geist, N.,Specht, R.,Schulze, S.,Palm, G.J.,Girbardt, B.,Dorre, B.,Berndt, L.,Kemnitz, S.,Doerr, M.,Bornscheuer, U.T.,Delcea, M.,Lammers, M. Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule. Nat Commun, 15:6002-6002, 2024 Cited by PubMed: 39019872 DOI: 10.1038/s41467-024-49952-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation