8RPL

AMP-forming acetyl-CoA synthetase from Chloroflexota bacterium with bound acetyl AMP

8RPL の概要

• エントリーDOI: 10.2210/pdb8rpl/pdb
• 分子名称: Acetate--CoA ligase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] ethanoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
• 機能のキーワード: acetate, acetyl-amp, coa, phospho histidine, acsa, ligase
• 由来する生物種: Chloroflexota bacterium
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 299072.22

構造登録者

Striska, K.,Palm, G.J.,Lammers, M. (登録日: 2024-01-16, 公開日: 2024-06-19, 最終更新日: 2024-07-31)

• 主引用文献: Qin, C.,Graf, L.G.,Striska, K.,Janetzky, M.,Geist, N.,Specht, R.,Schulze, S.,Palm, G.J.,Girbardt, B.,Dorre, B.,Berndt, L.,Kemnitz, S.,Doerr, M.,Bornscheuer, U.T.,Delcea, M.,Lammers, M.; Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule.; Nat Commun, 15:6002-6002, 2024; PubMed: 39019872; DOI: 10.1038/s41467-024-49952-0

実験手法

X-RAY DIFFRACTION (2.37 Å)