8RII

Structure of E166A BlaC from Mycobacterium tuberculosis at pH 6.5

Summary for 8RII

Entry DOI	10.2210/pdb8rii/pdb
Descriptor	Beta-lactamase (2 entities in total)
Functional Keywords	beta-lactamase, hydrolase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	28214.69
Authors	Sun, J.,Bruenle, S.,Ubbink, M. (deposition date: 2023-12-18, release date: 2024-08-28)
Primary citation	Sun, J.,Boyle, A.L.,Brunle, S.,Ubbink, M. A low-barrier proton shared between two aspartates acts as a conformational switch that changes the substrate specificity of the beta-lactamase BlaC. Int.J.Biol.Macromol., 278:134665-134665, 2024 Cited by PubMed: 39134195 DOI: 10.1016/j.ijbiomac.2024.134665 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation