8RHL

Yeast 20S proteasome in complex with a linear biarylether epoxyketone (compound 15a)

Summary for 8RHL

• Entry DOI: 10.2210/pdb8rhl/pdb
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total)
• Functional Keywords: proteasome, epoxomicin, tmc-95a, carfilzomib, macrocycle, binding analysis, hydrolase
• Biological source: Saccharomyces cerevisiae (brewer's yeast); More
• Total number of polymer chains: 32
• Total formula weight: 734190.59

Authors

Goetz, M.G.,Godwin, K.,Price, R.,Dorn, R.,Merrill-Steskal, G.,Hansen, H.,Klemmer, W.,Produturi, G.,Rocha, M.,Palmer, M.,Molacek, L.,Strater, Z.,Groll, M. (deposition date: 2023-12-15, release date: 2024-05-01)

• Primary citation: Gotz, M.G.,Godwin, K.,Price, R.,Dorn, R.,Merrill-Steskal, G.,Klemmer, W.,Hansen, H.,Produturi, G.,Rocha, M.,Palmer, M.,Molacek, L.,Strater, Z.,Groll, M.; Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome.; Acs Med.Chem.Lett., 15:533-539, 2024; PubMed: 38628795; DOI: 10.1021/acsmedchemlett.4c00017

Experimental method

X-RAY DIFFRACTION (3.2 Å)