8RHL
Yeast 20S proteasome in complex with a linear biarylether epoxyketone (compound 15a)
Summary for 8RHL
Entry DOI | 10.2210/pdb8rhl/pdb |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total) |
Functional Keywords | proteasome, epoxomicin, tmc-95a, carfilzomib, macrocycle, binding analysis, hydrolase |
Biological source | Saccharomyces cerevisiae (brewer's yeast) More |
Total number of polymer chains | 32 |
Total formula weight | 734190.59 |
Authors | Goetz, M.G.,Godwin, K.,Price, R.,Dorn, R.,Merrill-Steskal, G.,Hansen, H.,Klemmer, W.,Produturi, G.,Rocha, M.,Palmer, M.,Molacek, L.,Strater, Z.,Groll, M. (deposition date: 2023-12-15, release date: 2024-05-01) |
Primary citation | Gotz, M.G.,Godwin, K.,Price, R.,Dorn, R.,Merrill-Steskal, G.,Klemmer, W.,Hansen, H.,Produturi, G.,Rocha, M.,Palmer, M.,Molacek, L.,Strater, Z.,Groll, M. Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome. Acs Med.Chem.Lett., 15:533-539, 2024 Cited by PubMed: 38628795DOI: 10.1021/acsmedchemlett.4c00017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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