8REX

CryoEM structure of mouse GARP-lTGFbeta1 in complex with a Fab fragment derived from an activating antibody.

Summary for 8REX

• Entry DOI: 10.2210/pdb8rex/pdb
• EMDB information: 19111
• Descriptor: Transforming growth factor beta-1 proprotein, Transforming growth factor beta activator LRRC32, mFab LMT-12, Light Chain, ... (6 entities in total)
• Functional Keywords: garp, tgf-b1, activation, treg, immune system, antibody
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 9
• Total formula weight: 354609.07

Authors

Felix, J.,Lambert, F.,Marien, L.,van der Woning, B.,Savvides, S.N.,Lucas, S. (deposition date: 2023-12-12, release date: 2025-06-25)

• Primary citation: Lambert, F.,Felix, J.,Wautier, S.,Gaignage, M.,Dupre, E.,Marien, L.,Lesage, M.,van der Woning, B.,Coulie, P.G.,Savvides, S.N.,Lucas, S.; TGF-beta1 activating antibodies as novel immunotherapeutics for graft-versus-host disease.; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3 Å)