8RDP
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with spiro-isoxazol based compound 8a
This is a non-PDB format compatible entry.
Summary for 8RDP
Entry DOI | 10.2210/pdb8rdp/pdb |
Descriptor | Cereblon isoform 4, ZINC ION, (5~{S})-3-(2-chlorophenyl)-1-oxa-2,9-diazaspiro[4.5]dec-2-ene-8,10-dione, ... (6 entities in total) |
Functional Keywords | cereblon, ubiquitination, e3, molecular glue, spiro-isoxazole, signaling protein |
Biological source | Magnetospirillum gryphiswaldense |
Total number of polymer chains | 3 |
Total formula weight | 42260.99 |
Authors | |
Primary citation | Shevalev, R.,Bischof, L.,Sapegin, A.,Bunev, A.,Olga, G.,Kantin, G.,Kalinin, S.,Hartmann, M.D. Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode. Eur.J.Med.Chem., 270:116328-116328, 2024 Cited by PubMed: 38552426DOI: 10.1016/j.ejmech.2024.116328 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
Download full validation report