8RD1

HUWE1 WWE domain in complex with compound 4

Summary for 8RD1

Entry DOI	10.2210/pdb8rd1/pdb
Descriptor	E3 ubiquitin-protein ligase HUWE1, CHLORIDE ION, 2-(2-hydroxy-2-oxoethyl)-1,3-bis(oxidanylidene)isoindole-5-carboxylic acid, ... (4 entities in total)
Functional Keywords	wwe domain, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	43003.04
Authors	Muenzker, L.,Zak, K.M.,Boettcher, J. (deposition date: 2023-12-07, release date: 2024-07-31, Last modification date: 2024-08-07)
Primary citation	Munzker, L.,Kimani, S.W.,Fowkes, M.M.,Dong, A.,Zheng, H.,Li, Y.,Dasovich, M.,Zak, K.M.,Leung, A.K.L.,Elkins, J.M.,Kessler, D.,Arrowsmith, C.H.,Halabelian, L.,Bottcher, J. A ligand discovery toolbox for the WWE domain family of human E3 ligases. Commun Biol, 7:901-901, 2024 Cited by PubMed: 39048679 DOI: 10.1038/s42003-024-06584-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.896 Å)

Structure validation