8R99

A soakable crystal form of human CDK7 in complex with AMP-PNP

8R99 の概要

• エントリーDOI: 10.2210/pdb8r99/pdb
• 分子名称: Cyclin-dependent kinase 7, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: serine-threonine kinase, phosphorylation, cell cycle progression, atp binding, cell cycle
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42766.14

構造登録者

Mukherjee, M.,Cleasby, A. (登録日: 2023-11-30, 公開日: 2024-05-29, 最終更新日: 2024-06-26)

• 主引用文献: Mukherjee, M.,Day, P.J.,Laverty, D.,Bueren-Calabuig, J.A.,Woodhead, A.J.,Griffiths-Jones, C.,Hiscock, S.,East, C.,Boyd, S.,O'Reilly, M.; Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design.; Structure, 2024; PubMed: 38870939; DOI: 10.1016/j.str.2024.05.011

実験手法