8R80

SARS-CoV-2 Delta RBD in complex with XBB-9 Fab and an anti-Fab nanobody

8R80 の概要

• エントリーDOI: 10.2210/pdb8r80/pdb
• 関連するPDBエントリー: 8QRF 8QRG 8QSQ 8QTD
• 分子名称: XBB-9 Fab heavy chain, XBB-9 Fab light chain, Spike protein S1, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, rbd, ba.2.86, xbb.1.5, xbb.1.5.10, xbb.1.5.70, viral protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 169573.34

構造登録者

Zhou, D.,Ren, J.,Stuart, D.I. (登録日: 2023-11-27, 公開日: 2024-05-08, 最終更新日: 2024-10-23)

主引用文献

Liu, C.,Zhou, D.,Dijokaite-Guraliuc, A.,Supasa, P.,Duyvesteyn, H.M.E.,Ginn, H.M.,Selvaraj, M.,Mentzer, A.J.,Das, R.,de Silva, T.I.,Ritter, T.G.,Plowright, M.,Newman, T.A.H.,Stafford, L.,Kronsteiner, B.,Temperton, N.,Lui, Y.,Fellermeyer, M.,Goulder, P.,Klenerman, P.,Dunachie, S.J.,Barton, M.I.,Kutuzov, M.A.,Dushek, O.,Fry, E.E.,Mongkolsapaya, J.,Ren, J.,Stuart, D.I.,Screaton, G.R.
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Cell Rep Med, 5:101553-101553, 2024

PubMed Abstract: BA.2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains many mutations in the spike gene. It appears to have originated from BA.2 and is distinct from the XBB variants responsible for many infections in 2023. The global spread and plethora of mutations in BA.2.86 has caused concern that it may possess greater immune-evasive potential, leading to a new wave of infection. Here, we examine the ability of BA.2.86 to evade the antibody response to infection using a panel of vaccinated or naturally infected sera and find that it shows marginally less immune evasion than XBB.1.5. We locate BA.2.86 in the antigenic landscape of recent variants and look at its ability to escape panels of potent monoclonal antibodies generated against contemporary SARS-CoV-2 infections. We demonstrate, and provide a structural explanation for, increased affinity of BA.2.86 to ACE2, which may increase transmissibility.

PubMed: 38723626
DOI: 10.1016/j.xcrm.2024.101553

実験手法

X-RAY DIFFRACTION (4.03 Å)