8R7O

HUWE1 WWE domain in complex with 2'F-ATP

Summary for 8R7O

Entry DOI	10.2210/pdb8r7o/pdb
Descriptor	E3 ubiquitin-protein ligase HUWE1, CHLORIDE ION, [[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-fluoranyl-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, ... (5 entities in total)
Functional Keywords	wwe domain, ligase, nucleotide
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	43225.94
Authors	Muenzker, L.,Boettcher, J. (deposition date: 2023-11-27, release date: 2024-07-31)
Primary citation	Munzker, L.,Kimani, S.W.,Fowkes, M.M.,Dong, A.,Zheng, H.,Li, Y.,Dasovich, M.,Zak, K.M.,Leung, A.K.L.,Elkins, J.M.,Kessler, D.,Arrowsmith, C.H.,Halabelian, L.,Bottcher, J. A ligand discovery toolbox for the WWE domain family of human E3 ligases Commun Biol, 7:901-, 2024 Cited by DOI: 10.1038/s42003-024-06584-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.36 Å)

Structure validation