8R7G

Crystal structure of the kinase domain of ACVR1 (ALK2) with M4K2234

8R7G の概要

• エントリーDOI: 10.2210/pdb8r7g/pdb
• 分子名称: Activin receptor type I, 2-fluoranyl-6-methoxy-4-[4-methyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pyridin-3-yl]benzamide (3 entities in total)
• 機能のキーワード: alk2, acvr1, kinase, inhibitor, m4k2234, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 140000.77

構造登録者

Williams, E.P.,Cros, J.,Ensan, D.,Smil, D.,Edwards, A.M.,O'Meara, J.A.,Fernandez-Cid, A.,Isaac, M.B.,Al-awar, R.,Bullock, A.N. (登録日: 2023-11-24, 公開日: 2024-04-03)

• 主引用文献: Ensan, D.,Smil, D.,Zepeda-Velazquez, C.A.,Panagopoulos, D.,Wong, J.F.,Williams, E.P.,Adamson, R.,Bullock, A.N.,Kiyota, T.,Aman, A.,Roberts, O.G.,Edwards, A.M.,O'Meara, J.A.,Isaac, M.B.,Al-Awar, R.; Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.; J.Med.Chem., 63:4978-4996, 2020; PubMed: 32369358; DOI: 10.1021/acs.jmedchem.0c00395

実験手法

X-RAY DIFFRACTION (2.09 Å)