8R7C

MutSbeta bound to compound CHDI-00915542 in the canonical DNA-mismatch bound form

8R7C の概要

• エントリーDOI: 10.2210/pdb8r7c/pdb
• 分子名称: DNA mismatch repair protein Msh2, SULFATE ION, DNA mismatch repair protein Msh3, ... (11 entities in total)
• 機能のキーワード: proteros biostructures gmbh, dna binding protein, dna mismatch repair
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 449092.94

構造登録者

Thomsen, M.,Thieulin-Pardo, G.,Steinbacher, S.,Brace, G.,Tillack, K.,Johnson, P.,Ritzefeld, M.,Schaertl, S.,Frush, E.,Warfield, B.,Ballantyne, G.,Lee, J.-H.,Witte, D.,Finley, M.,Prasad, B.,Monteagudo, E.,Plotnikov, N.,Pacifici, R.,Maillard, M.,Wilkinson, H.,Iyer, R.,Dominguez, C.,Vogt, T.,Felsenfeld, D.,Haque, T. (登録日: 2023-11-24, 公開日: 2024-11-27)

• 主引用文献: Brace, G.,Tillack, K.,Johnson, P.,Ritzefeld, M.,Schaertl, S.,Frush, E.,Warfield, B.,Ballantyne, G.,Lee, J.-H.,Thieulin-Pardo, G.,Steinbacher, S.,Thomsen, M.,Witte, D.,Finley, M.,Prasad, B.,Monteagudo, E.,Plotnikov, N.,Pacifici, R.,Maillard, M.,Wilkinson, H.,Iyer, R.,Dominguez, C.,Vogt, T.,Felsenfeld, D.,Haque, T.; Identification of orthosteric inhibitors of MutSbeta ATPase function; Chemrxiv, 2024; DOI: 10.26434/chemrxiv-2024-74zr6

実験手法

X-RAY DIFFRACTION (2.82 Å)