8R74

Galectin-1 in complex with thiogalactoside derivative

8R74 の概要

• エントリーDOI: 10.2210/pdb8r74/pdb
• 分子名称: Galectin-1, (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(2-oxidanyl-1,3-thiazol-4-yl)-1,2,3-triazol-1-yl]oxane-3,5-diol (3 entities in total)
• 機能のキーワード: galectin, ligand, thiogalactoside derivative, sugar binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30444.09

構造登録者

Hakansson, M.,Diehl, C.,Peterson, K.,Zetterberg, F.,Nilsson, U. (登録日: 2023-11-23, 公開日: 2024-06-05, 最終更新日: 2024-06-19)

• 主引用文献: Zetterberg, F.R.,Peterson, K.,Nilsson, U.J.,Andreasson Dahlgren, K.,Diehl, C.,Holyer, I.,Hakansson, M.,Khabut, A.,Kahl-Knutson, B.,Leffler, H.,MacKinnon, A.C.,Roper, J.A.,Slack, R.J.,Zarrizi, R.,Pedersen, A.; Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer.; J.Med.Chem., 67:9374-9388, 2024; PubMed: 38804039; DOI: 10.1021/acs.jmedchem.4c00485

実験手法

X-RAY DIFFRACTION (1.54 Å)