8R62
Solution structure of Risdiplam bound to the RNA duplex formed upon 5'-splice site recognition
Summary for 8R62
Entry DOI | 10.2210/pdb8r62/pdb |
NMR Information | BMRB: 34878 |
Descriptor | RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3'), 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-1~{H}-pyrido[1,2-a]pyrimidin-4-one (3 entities in total) |
Functional Keywords | rna splicing correction, small molecule splicing modifier, molecular glue, rna |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 7377.71 |
Authors | Malard, F.,Campagne, S. (deposition date: 2023-11-20, release date: 2024-03-06, Last modification date: 2024-05-22) |
Primary citation | Malard, F.,Wolter, A.C.,Marquevielle, J.,Morvan, E.,Ecoutin, A.,Rudisser, S.H.,Allain, F.H.T.,Campagne, S. The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design. Nucleic Acids Res., 52:4124-4136, 2024 Cited by PubMed: 38554107DOI: 10.1093/nar/gkae201 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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