8R5D

Crystal structure of human TRIM7 PRYSPRY domain

Summary for 8R5D

• Entry DOI: 10.2210/pdb8r5d/pdb
• Descriptor: E3 ubiquitin-protein ligase TRIM7, MALONIC ACID, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: trim7, e3-ligase, structural genomics, structural genomics consortium, sgc, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 40673.83

Authors

Munoz Sosa, C.J.,Kraemer, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-11-16, release date: 2024-01-17, Last modification date: 2024-07-31)

• Primary citation: Munoz Sosa, C.J.,Lenz, C.,Hamann, A.,Farges, F.,Dopfer, J.,Kramer, A.,Cherkashyna, V.,Tarnovskiy, A.,Moroz, Y.S.,Proschak, E.,Nemec, V.,Muller, S.,Saxena, K.,Knapp, S.; A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7.; Acs Chem.Biol., 19:1638-1647, 2024; PubMed: 38934237; DOI: 10.1021/acschembio.4c00301

Experimental method

X-RAY DIFFRACTION (1.8 Å)