8R4U

Structure of salt-inducible kinase 3 with inhibitors

8R4U の概要

• エントリーDOI: 10.2210/pdb8r4u/pdb
• 分子名称: Serine/threonine-protein kinase SIK3, scFvH1, 8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[2-chloranyl-4-(3-fluoranylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, ... (5 entities in total)
• 機能のキーワード: kinase, inhibitor complex, drug design, ampk-like kinase, uba, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 263571.46

構造登録者

Kack, H.,Oster, L. (登録日: 2023-11-14, 公開日: 2024-03-27, 最終更新日: 2024-05-08)

• 主引用文献: Oster, L.,Castaldo, M.,de Vries, E.,Edfeldt, F.,Pemberton, N.,Gordon, E.,Cederblad, L.,Kack, H.; The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity.; J.Biol.Chem., 300:107201-107201, 2024; PubMed: 38508313; DOI: 10.1016/j.jbc.2024.107201

実験手法

X-RAY DIFFRACTION (2.416 Å)