8R1V

Pseudomonas aeruginosa FabF C164A in complex with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-methoxyphenoxy)acetamide

8R1V の概要

• エントリーDOI: 10.2210/pdb8r1v/pdb
• 関連するPDBエントリー: 8R0I
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-methoxyphenoxy)acetamide, DIMETHYL SULFOXIDE, ... (5 entities in total)
• 機能のキーワード: inhibitor, protein-ligand complex, fabf, transferase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89206.23

構造登録者

Yadrykhinsky, V.,Brenk, R. (登録日: 2023-11-02, 公開日: 2024-03-06, 最終更新日: 2024-05-08)

• 主引用文献: Jalencas, X.,Berg, H.,Espeland, L.O.,Sreeramulu, S.,Kinnen, F.,Richter, C.,Georgiou, C.,Yadrykhinsky, V.,Specker, E.,Jaudzems, K.,Miletic, T.,Harmel, R.,Gribbon, P.,Schwalbe, H.,Brenk, R.,Jirgensons, A.,Zaliani, A.,Mestres, J.; Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection.; Rsc Med Chem, 15:1176-1188, 2024; PubMed: 38665834; DOI: 10.1039/d3md00724c

実験手法

X-RAY DIFFRACTION (2.087 Å)