8R03
Staphylococcus aureus ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.0 A resolution
Summary for 8R03
Entry DOI | 10.2210/pdb8r03/pdb |
Related | 3V5E |
Descriptor | ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound), 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | anti-virulence, caseinolytic protease, inhibitor, natural product, mode of action, hydrolase |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 14 |
Total formula weight | 307713.78 |
Authors | Illigmann, A.,Vielberg, M.-T.,Lakemeyer, M.,Wolf, F.,Staudt, N.,Dema, T.,Stange, P.,Liebhart, E.,Kuttenlochner, W.,Kulik, A.,Malik, I.,Grond, S.,Sieber, S.A.,Groll, M.,Kaysser, L.,Broetz-Oesterhelt, H. (deposition date: 2023-10-30, release date: 2023-12-20, Last modification date: 2024-01-24) |
Primary citation | Illigmann, A.,Vielberg, M.T.,Lakemeyer, M.,Wolf, F.,Dema, T.,Stange, P.,Kuttenlochner, W.,Liebhart, E.,Kulik, A.,Staudt, N.D.,Malik, I.,Grond, S.,Sieber, S.A.,Kaysser, L.,Groll, M.,Brotz-Oesterhelt, H. Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63:e202314028-e202314028, 2024 Cited by PubMed: 38029352DOI: 10.1002/anie.202314028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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