8QUS
Crystal structure of the Plasmodium vivax Apical membrane antigen (AMA1) in complex with single domain i-body WD34
Summary for 8QUS
| Entry DOI | 10.2210/pdb8qus/pdb |
| Descriptor | Apical merozoite antigen 1, single domain i-body WD34 (2 entities in total) |
| Functional Keywords | plasmodium, ama1, i-body, protein binding |
| Biological source | Plasmodium vivax Sal-1 More |
| Total number of polymer chains | 2 |
| Total formula weight | 67350.64 |
| Authors | Maddumage, J.C.,Kvansakul, M. (deposition date: 2023-10-17, release date: 2024-07-03, Last modification date: 2024-09-04) |
| Primary citation | Angage, D.,Chmielewski, J.,Maddumage, J.C.,Hesping, E.,Caiazzo, S.,Lai, K.H.,Yeoh, L.M.,Menassa, J.,Opi, D.H.,Cairns, C.,Puthalakath, H.,Beeson, J.G.,Kvansakul, M.,Boddey, J.A.,Wilson, D.W.,Anders, R.F.,Foley, M. A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites. Nat Commun, 15:7206-7206, 2024 Cited by PubMed: 39174515DOI: 10.1038/s41467-024-50770-7 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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