8QUC
Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT1
Summary for 8QUC
Entry DOI | 10.2210/pdb8quc/pdb |
EMDB information | 18659 |
Descriptor | Potassium voltage-gated channel subfamily C member 1, (5R)-5-ethyl-3-[6-(3-methoxy-4-methyl-phenoxy)pyridin-3-yl]imidazolidine-2,4-dione, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, ... (7 entities in total) |
Functional Keywords | modulator, homotetramer, voltage-gated potassium channel, membrane protein, kv3.1, kcnc1 |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 242105.94 |
Authors | Chi, G.,Mckinley, G.,Marsden, B.,Pike, A.C.W.,Ye, M.,Brooke, L.M.,Bakshi, S.,Pilati, N.,Marasco, A.,Gunthorpe, M.,Alvaro, G.,Large, C.,Lakshminaraya, B.,Williams, E.,Sauer, D.B. (deposition date: 2023-10-16, release date: 2024-04-03) |
Primary citation | Liang, Q.,Chi, G.,Cirqueira, L.,Zhi, L.,Marasco, A.,Pilati, N.,Gunthorpe, M.J.,Alvaro, G.,Large, C.H.,Sauer, D.B.,Treptow, W.,Covarrubias, M. The binding and mechanism of a positive allosteric modulator of Kv3 channels. Nat Commun, 15:2533-2533, 2024 Cited by PubMed: 38514618DOI: 10.1038/s41467-024-46813-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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