8QU7

Crystal structure of the Plasmodium falciparum Apical membrane antigen (AMA1) in complex with single domain i-body WD34

Summary for 8QU7

Entry DOI	10.2210/pdb8qu7/pdb
Descriptor	Apical membrane antigen 1, single domain i-body WD34, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (6 entities in total)
Functional Keywords	plasmodium, ama1, i-body, protein binding
Biological source	Plasmodium falciparum 3D7 More
Total number of polymer chains	2
Total formula weight	55645.25
Authors	Maddumage, J.C.,Kvansakul, M. (deposition date: 2023-10-14, release date: 2024-07-03, Last modification date: 2024-09-04)
Primary citation	Angage, D.,Chmielewski, J.,Maddumage, J.C.,Hesping, E.,Caiazzo, S.,Lai, K.H.,Yeoh, L.M.,Menassa, J.,Opi, D.H.,Cairns, C.,Puthalakath, H.,Beeson, J.G.,Kvansakul, M.,Boddey, J.A.,Wilson, D.W.,Anders, R.F.,Foley, M. A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites. Nat Commun, 15:7206-7206, 2024 Cited by PubMed: 39174515 DOI: 10.1038/s41467-024-50770-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation