8QU7

Crystal structure of the Plasmodium falciparum Apical membrane antigen (AMA1) in complex with single domain i-body WD34

Summary for 8QU7

• Entry DOI: 10.2210/pdb8qu7/pdb
• Descriptor: Apical membrane antigen 1, single domain i-body WD34, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (6 entities in total)
• Functional Keywords: plasmodium, ama1, i-body, protein binding
• Biological source: Plasmodium falciparum 3D7; More
• Total number of polymer chains: 2
• Total formula weight: 55645.25

Authors

Maddumage, J.C.,Kvansakul, M. (deposition date: 2023-10-14, release date: 2024-07-03)

• Primary citation: Foley, M.,Angage, D.,Anders, R.,Chmielewski, J.,Maddumage, J.C.,Hesping, E.,Caiazzo, S.,Lai, K.H.,Yeoh, L.,Opi, H.,Cairns, C.,Beeson, J.,Kvansakul, M.,Wilson, D.,Boddey, J.; A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites; Res Sq, 2024; DOI: 10.21203/rs.3.rs-3671797/v1

Experimental method

X-RAY DIFFRACTION (2.6 Å)