8QT2

Crystal structure of human Sirt2 in complex with the super-slow substrate TNFn-6

Summary for 8QT2

• Entry DOI: 10.2210/pdb8qt2/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-2, Peptide-based super-slow substrate TNFn-6, ZINC ION, ... (8 entities in total)
• Functional Keywords: super-slow substrate, sirtuin 2, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 36153.20

Authors

Friedrich, F.,Kalbas, D.,Meleshin, M.,Einsle, O.,Schutkowski, M.,Jung, M. (deposition date: 2023-10-12, release date: 2024-10-23)

• Primary citation: Friedrich, F.,Kalbas, D.,Einsle, O.,Jung, M.,Schutkowski, M.; New Super-Slow Substrates as novel Sirtuin-Inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.65 Å)