8QSG

Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 86 (1124384).

Summary for 8QSG

• Entry DOI: 10.2210/pdb8qsg/pdb
• Descriptor: 14-3-3 protein sigma, BRAF peptide pS365, 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone, ... (6 entities in total)
• Functional Keywords: 14-3-3, protein-protein interaction stabilizer, peptide binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 56207.89

Authors

Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. (deposition date: 2023-10-10, release date: 2025-04-23)

• Primary citation: Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R.; Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)