8QSC

Ternary structure of 14-3-3s, ARAF phosphopeptide (pS214) and compound 22 (1083853).

Summary for 8QSC

• Entry DOI: 10.2210/pdb8qsc/pdb
• Descriptor: 14-3-3 protein sigma, ARAF peptide pS214, ~{N}-[[1-(4-bromophenyl)sulfonylpiperidin-4-yl]methyl]-2-chloranyl-ethanamide, ... (6 entities in total)
• Functional Keywords: 14-3-3, protein-protein interaction stabilizer, peptide binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 56746.51

Authors

Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. (deposition date: 2023-10-10, release date: 2025-04-23)

• Primary citation: Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R.; Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)