8QPZ

CryoEM structure of recombinant DeltaN7 alpha-synuclein in PBS

Summary for 8QPZ

Entry DOI	10.2210/pdb8qpz/pdb
EMDB information	18570
Descriptor	Alpha-synuclein (1 entity in total)
Functional Keywords	synuclein, parkinson's disease, neurodegeneration, amyloid, helical, fibril, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	12
Total formula weight	165567.43
Authors	Thacker, D.,Wilkinson, M.,Dewison, K.M.,Ranson, N.A.,Brockwell, D.J.,Radford, S.E. (deposition date: 2023-10-03, release date: 2024-09-04)
Primary citation	Dewison, K.M.,Rowlinson, B.,Machin, J.M.,Crossley, J.A.,Thacker, D.,Wilkinson, M.,Ulamec, S.M.,Khan, G.N.,Ranson, N.A.,van Oosten-Hawle, P.,Brockwell, D.J.,Radford, S.E. Residues 2 to 7 of alpha-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways. Proc.Natl.Acad.Sci.USA, 121:e2315006121-e2315006121, 2024 Cited by PubMed: 39133842 DOI: 10.1073/pnas.2315006121 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation