8QJX

Human Adenovirus type 11 fiber knob in complex with two copies of its cell receptor, Desmoglein-2

Summary for 8QJX

• Entry DOI: 10.2210/pdb8qjx/pdb
• EMDB information: 18453
• Descriptor: Desmoglein-2, Fiber protein (2 entities in total)
• Functional Keywords: adenovirus, cell entry, receptor binding, viral protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 351537.59

Authors

Effantin, G. (deposition date: 2023-09-14, release date: 2023-11-01, Last modification date: 2023-12-13)

Primary citation

Effantin, G.,Hograindleur, M.-.A.,Fenel, D.,Fender, P.,Vassal-Stermann, E.
Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.
J.Virol., 97:e0091023-e0091023, 2023

PubMed Abstract: The main limitation of oncolytic vectors is neutralization by blood components, which prevents intratumoral administration to patients. Enadenotucirev, a chimeric HAdV-11p/HAdV-3 adenovirus identified by bio-selection, is a low seroprevalence vector active against a broad range of human carcinoma cell lines. At this stage, there's still some uncertainty about tropism and primary receptor utilization by HAdV-11. However, this information is very important, as it has a direct influence on the effectiveness of HAdV-11-based vectors. The aim of this work is to determine which of the two receptors, DSG2 and CD46, is involved in the attachment of the virus to the host, and what role they play in the early stages of infection.

PubMed: 37921471
DOI: 10.1128/jvi.00910-23

Experimental method

ELECTRON MICROSCOPY (3.3 Å)