8QJX

Human Adenovirus type 11 fiber knob in complex with two copies of its cell receptor, Desmoglein-2

8QJX の概要

• エントリーDOI: 10.2210/pdb8qjx/pdb
• EMDBエントリー: 18453
• 分子名称: Desmoglein-2, Fiber protein (2 entities in total)
• 機能のキーワード: adenovirus, cell entry, receptor binding, viral protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 351537.59

構造登録者

Effantin, G. (登録日: 2023-09-14, 公開日: 2023-11-01, 最終更新日: 2023-12-13)

主引用文献

Effantin, G.,Hograindleur, M.-.A.,Fenel, D.,Fender, P.,Vassal-Stermann, E.
Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.
J.Virol., 97:e0091023-e0091023, 2023

PubMed Abstract: The main limitation of oncolytic vectors is neutralization by blood components, which prevents intratumoral administration to patients. Enadenotucirev, a chimeric HAdV-11p/HAdV-3 adenovirus identified by bio-selection, is a low seroprevalence vector active against a broad range of human carcinoma cell lines. At this stage, there's still some uncertainty about tropism and primary receptor utilization by HAdV-11. However, this information is very important, as it has a direct influence on the effectiveness of HAdV-11-based vectors. The aim of this work is to determine which of the two receptors, DSG2 and CD46, is involved in the attachment of the virus to the host, and what role they play in the early stages of infection.

PubMed: 37921471
DOI: 10.1128/jvi.00910-23

実験手法

ELECTRON MICROSCOPY (3.3 Å)